Welcome to the NIH Collaboratory E-Newsletter! The newsletter is intended to provide a convenient monthly wrap-up of NIH Collaboratory news, along with featured stories and a look at what’s coming in the month ahead. We hope you’ll find it useful, and we’d love to hear your feedback. Please let us know what you think.
Recent News

Reflections From the Patient-Reported Outcomes Core: Dr. Kevin Weinfurt, chair of the Patient-Reported Outcomes (PRO) Core, shares the successes of the first 5 years of the Core and looks ahead to the coming years: “We need to determine when PROs are essential, supporting, or not at all informative for the clinical questions. This gets at the value proposition: When are they of value and to whom?”

NCI Announces Training Institute in Dissemination and Implementation Research in Cancer: The National Cancer Institute is accepting applications for a Training Institute in Dissemination and Implementation Research in Cancer (TIDIRC). Designed for investigators at all levels, this cancer-focused training program will consist of a 4-month online course and a 2-day in-person training. The application window will close on February 9.

“All of Us” Research Program Asks for Research Ideas: The groundbreaking program is asking researchers, community organizations, and citizen scientists for suggestions of potential research questions. The deadline is February 19.

Implementation of Revised Common Rule Delayed: Federal departments and agencies announced a delay in the effective and compliance dates for the revised Common Rule. The delay will give institutions additional time to prepare to implement the revisions.

New Research Methods Resources Website on Group- or Cluster-Randomized Studies: NIH released new clinical trial requirements for grant applications and contract proposals. The new Research Methods Resources website provides resources for investigators considering group- or cluster-randomized designs.
Grand Rounds Roundup
Podcasts

Don't miss our latest Grand Rounds podcast: In this episode, Drs. Richard Platt and Christopher Granger speak with moderator Dr. Adrian Hernandez about the IMPACT-AFib trial. Researchers used pharmacy data from the FDA’s Sentinel Initiative to identify more than 80,000 potential participants.

Other recent Grand Rounds podcasts:


Latest Grand Rounds

IMPACT-AFib: An 80,000 person Randomized Trial Using the Sentinel Initiative Platform (Noelle M. Cocoros, DSc, MPH; Christopher B. Granger, MD, FACC, FAHA; Richard Platt MD, MS; Sean Pokorney, MD)


Video Update
What is a Pragmatic Trial? Dr. Greg Simon uses props to explain pragmatic trials and their importance in clinical research. “Doctors, nurses, and other health care providers face lots of decisions. Pragmatic clinical trials are about helping doctors make better decisions to take care of their patients.”
Trial Spotlight
The goal of the TSOS trial, an NIH Collaboratory Demonstration Project, is to coordinate care and improve outcomes of trauma survivors with posttraumatic stress disorder (PTSD) at two dozen level 1 trauma centers in the United States. Because evidence-based treatments for patients with PTSD have not been broadly implemented in US trauma care systems, the TSOS trial also aims to provide evidence to inform regulatory policy. In a recent interview, principal investigator Dr. Doug Zatzick discussed the status of the trial, challenges and surprises, and advice for new investigators. Download a study snapshot about this trial.
Featured Publications & Products
Find tips on participant recruitment for pragmatic clinical trials in the Living Textbook, including how to evaluate characteristics and capabilities of partner health care systems.
How do you establish the feasibility of a pragmatic trial? Get help from the Living Textbook, including tips on pilot testing and real-world examples from NIH Collaboratory trials.