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Spotlight on: Dr. Richard Aplenc
Appointed Chief Clinical Research Officer

CPCE congratulates Core Faculty member Richard Aplenc, MD, PhD, MSCE on his appointment to the role of Chief Clinical Research Officer, a critical leadership position within the Research Institute. Bryan Wolf, MD, PhD, Chief Scientific Officer, announced the appointment via e-mail to CHOP principal investigators and research staff last month, following an extensive internal search.

Dr. Aplenc came to CHOP for his Pediatric Hematology Oncology fellowship in 1997, joined the faculty in 2002, and is currently a Professor of Pediatrics as well as a Professor of Epidemiology. He also serves as the Section Chief of Hematologic Malignancies at CHOP, in addition to his role as a CPCE core faculty member.

His robust research program focuses on acute myeloid leukemia, particularly AML therapeutics as well as clinical and genetic epidemiology studies focused on improving clinical outcomes for pediatric patients. He has extensive mentoring and training experience, including several fellows in CPCE-managed postdoctoral fellowship training programs .

Read more from Cornerstone .
Upcoming Events
Clinical Trials Research Affinity Group Seminar
Date: February 28, 2018
Time: 12:00 - 1:00 pm
Location: Roberts Center for Pediatric Research, 2nd Floor, Room 2170
Kristina Harr, JD, Administrative Director of Clinical Trial Support Services, will be giving a presentation on OnCore. For more information or to RSVP, contact ClinicalTrialsRAG@email.chop.edu.

Save the Date: 10th Annual CHOP Research Safety Day
Date: April 19, 2018
Time: 10:00 am - 2:00 pm
Location: Colket Translational Research Building lobby and conference rooms
Formal invitations and more details will follow soon. Please feel free to contact Research Safety with any questions at (267) 426-2272 or at researchsafety@email.chop.edu.

CHOP Quality and Safety Day 2018
Date: May 15, 2018
Time: 8:00 am - 4:00 pm
Location: Stokes Auditorium, CHOP Main Hospital
Paula Davis-Laak, JD, MAPP, will present the keynote address, “Thriving in Healthcare: Your Blueprint for Stress Resilience.”  Register for the conference or submit an abstract that highlights the way your team has applied the CHOP Improvement Framework, Safety Behaviors for Error Prevention, or other strategies. Abstracts are due Friday March 30, 2018 at 5:00 pm.

Penn MSHP 2018 Implementation Science Institute
Dates: June 19 - 21, 2018
Location: Jordan Medical Education Center
The purpose of the Implementation Science Institute is to provide participants with the tools to design and execute rigorous implementation science research. The Institute will give an introduction to the foundations of implementation science, cover implementation strategies and sustainability, tips for grant writing and skill development. Limited scholarships will be available for affiliates of CHOP. Register here or contact mshp@mail.med.upenn.edu for more information.
CPCE in
the News!
Recent Publications
Dr. Susan Coffin and colleagues conducted a retrospective chart review to determine the clinical diagnoses associated with the National Healthcare Safety Network (NHSN) pneumonia or lower respiratory infection surveillance events In adults not on mechanical ventilation and in children, most NHSN-defined pneumonia events corresponded with compatible clinical conditions documented in the medical record. In contrast, NHSN lower respiratory events often did not. As a result, substantial modifications to the lower respiratory events definitions were implemented in 2015.

In response to the growing epidemic of antibiotic-resistant bacterial infections, antimicrobial stewardship programs have been rapidly implemented in the United States. This study examines the prevalence of the Centers for Disease Control and Prevention's seven core elements of a successful antimicrobial stewardship program within a large subset of US Children's Hospitals.

The concepts of medical futility and "potentially inappropriate" interventions aim to describe particular decision-making situations and assist in making ethically sound decisions. This article explores how both of these concepts simplify the rather more complicated decision-making task in ways that often hinder their ability to be helpful, and potentially allow for unstated biases to influence decisions. 

Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faecalibacterium prausnitzii and abnormalities in both directions in the abundance of the Bacteroides genus have been identified. Dr. Weiss and colleagues obtained fecal specimens from 30 children with treatment-naïve enthesitis-related arthritis (ERA) and 19 healthy controls, as well as specimens from 11 adult patients with longstanding SpA and 10 adult healthy controls to study differences between the samples. 

The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research approaches. Innovative comparative effectiveness approaches are needed to efficiently study treatment approaches and disease outcomes. Dr. Weiss, as a member of The Childhood Arthritis and Rheumatology Research Alliance (CARRA), assisted with developed the consensus treatment plan (CTP) approach as a comparative effectiveness tool for research in pediatric rheumatology.

Funding Opportunities
The Health Effects Institute is a nonprofit corporation chartered in 1980 to provide high-quality, impartial, and relevant science on the health effects of air pollution. HEI established the Walter A. Rosenblith New Investigator Award to provide funding to outstanding investigators who are beginning independent research. Each award will grant up to $150,000 per year, with a maximum of $450,000 over three years. Scientists of any nationality holding a PhD, ScD, MD, DVM, or DrPH degree or equivalent are eligible to apply. 

NKF will award grants of up to $35,000 in support of research projects in the field of nephrology and related disciplines conducted by individuals who have completed fellowship training and who hold a junior faculty position at a university-affiliated medical center in the United States. Projects must be patient-oriented. Elements of patient-oriented research activities may include but are not limited to development of new technologies, mechanisms of human disease, educational or therapeutic interventions, epidemiological studies, health policy studies, and clinical trials.

The CHOP Pediatric Center of Excellence in Nephrology (CHOP PCEN) was established to break down barriers to implementing clinical trials in childhood kidney disease. The CHOP PCEN will support two research projects funded to a maximum of $50,000 per year for up to two years. The pilot projects must utilize at least one of the CHOP PCEN cores and focus on research that will accelerate the pace of clinical trials in nephrology.

Frontier Programs differentiate CHOP as innovators because of their unique combination of translational research and exceptional clinical care of children with highly complex conditions. These programs are vital to CHOP’s mission, reputation and financial well-being and contribute to our success regionally, nationally and internationally. Selected programs will be eligible to receive up to $1M in the first year and $1.5M per year for 1-2 additional years. If selected, the funding will be effective July 1, 2018.

The mission of the Rita & Alex Hillman Foundation is to improve the lives of patients and their families through nursing-driven innovation. The foundation currently is accepting proposals for innovative patient- and family-centered approaches that challenge conventional strategies, improve health outcomes, lower costs, and enhance the patient and family caregiver experience. The foundation is particularly interested in the areas of maternal and child health, care of the older adult, and chronic illness management. Two grants of up to $600,000 will be awarded in 2018.

The Institutional Intellectual and Developmental Disabilities Research Center at CHOP/Penn announces funding to support pilot projects relevant to elucidating the causes of and/or developing potential new therapies for intellectual or developmental disabilities. These pilot projects may be basic, translational, or clinical research. Applicants must hold a faculty appointment as an Assistant Professor for less than four years from the date of appointment by July 1, 2018. The center expects to issue three awards of up to $50,000 per year for two years.

The Thrasher Research Fund provides grants for clinical, hypothesis-driven research that offers substantial promise for meaningful advances in the prevention, diagnosis, and treatment of children's diseases, particularly research that offers broad-based applications. The fund is inviting concept papers for its Early Career Awards Grants program. Through the program, the fund awards small grants of up to $25,000 to new researchers to help them gain a foothold in the area of pediatric research. The program will consider a variety of research topics important to children's health but will give priority to applicants who show great potential to impact children's health through medical research.

The Damon Runyon Cancer Research Foundation has joined together with the Sohn Conference Foundation, dedicated to curing pediatric cancers, to establish the Damon Runyon-Sohn Pediatric Cancer Fellowship Award. This award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers.

Grants of up to $20,000 are available to help support the research of faculty members or post-doctoral researchers affiliated with non-profit human service organizations in the United States and Canada. Areas of interest to the Fund are: studies to develop, refine, evaluate, or disseminate innovative interventions designed to prevent or ameliorate major social, psychological, behavioral or public health problems affecting children, adults, couples, families, or communities, or studies that have the potential for adding significantly to knowledge about such problems.

The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures. The total requested grant size should be no more than $350,000.

The American Legion Child Welfare Foundation supports organizations that contribute to the physical, mental, emotional, and spiritual welfare of children. The foundation awards grants for the dissemination of information about new and innovative programs designed to benefit youth or information already possessed by well-established organizations. Projects must have the potential to help American children in a large geographic area (more than one state).

Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: