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In Vitro Exposure Systems
and Dosimetry Assessment Tools for
Inhaled Tobacco Products
Workshop Agenda
April 4-6th, 2016
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April 4, 2016 - 8:00-6:00
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8:00-9:00
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Continental Breakfast and Registration
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9:00-9:15
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Welcome and Overview
Holger Behrsing, IIVS
Raymond Tice, NIEHS (retired)
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9:15-9:30
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Advancing Regulatory Science at the US FDA with More Predictive Models
Suzanne Fitzpatrick, FDA
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9:30-9:45
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In Vitro
to In Vivo Extrapolation in Humans
Robert Devlin, US EPA
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9:45-10:15
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In Vitro
Models for Tobacco Regulatory Science: Collaborative Efforts in Respiratory Toxicology
Hans Raabe. IIVS
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| 10:15-10:45 |
Break
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10:45-11:15
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Species Differences in Respiratory Anatomy
Kent Pinkerton, University of California, Davis
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11:15-11:45
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Considerations and Challenges for In Vivo/In Vitro Correlations
Günter Oberdörster, University of Rochester
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11:45-1:15
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Lunch - followed by Poster Viewing
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Core Subject 1: Tobacco Smoke and E-cigarette Aerosols
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1:15-2:00
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Now You See It - Now You Don't: The Chemistry of Cigarette Smoke and
E-cigarette Aerosols
Chris Wright, British American Tobacco
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2:00-2:15
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Discussion: Tobacco Smoke and E-cigarette Aerosols
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2:15-2:30
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Break
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Core Subject 2: Air Liquid Interface -
In Vitro
Exposure Systems
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2:30-3:00
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Fresh Smoke ALI Exposure in 24 and 96 Multiwell Plates Using a New Smoke Exposure
In Vitro System (SEIVS)
Roman Wieczorek, ITG
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3:00-3:30
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Air-Liquid Interface - In Vitro Exposure Systems and Their Use in Inhalation Toxicology
Michaela Aufderheide, Cultex Laboratories GmbH
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3:30-3:45
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Break
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3:45-4:15
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A New Fluorescence Based Method for Characterization of In Vitro Aerosol Exposure Systems
Sandro Steiner, Philip Morris International
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4:15-4:45
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Cutting Edge In Vitro Exposure Technologies for Conventional and E-cigarettes
Tobias Krebs, Vitrocell Systems GmbH
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4:45-5:00
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Panel Discussion: Air-Liquid Interface - In Vitro Exposure Systems |
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5:00-6:00
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Poster Reception |
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6:00
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Dinner
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April 5, 2016 - 8:30-6:30
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| 8:30-9:00 |
Continental Breakfast
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Core Subject 3a: Dosimetry Approaches for Particles and Vapors
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| 9:00-9:30 |
Modeling Inhalation and Deposition of Cigarette Puff Mixture in the Lungs of Smokers
Bahman Asgharian, Applied Research Associates
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9:30-10:00
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CFD Modeling of Aerosols and Vapors for Cross-Species and IVIVE Respiratory Dosimetry
Richard Corley, Pacific Northwest National Laboratory
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10:00-10:30
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Deterministic Dosimetry for Particles and Vapors: Considerations for
In-Vitro Mainstream Tobacco Smoke
and E-Vapor Product Studies
Michael Oldham, Altria
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10:30-10:45
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Panel Discussion:
Dosimetry Approaches for Particles and Vapors
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10:45-11:15
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Break
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Core Subject 3b:
In Vitro
Dosimetry Determinations
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11:15-11:45
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Dosimetry Tools, Approaches and Applications for Tobacco and Next Generation Product Testing
Jason Adamson, British American Tobacco
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11:45-12:15
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Evaluation Method for In Vitro Toxicity of Cigarette Smoke by Whole Smoke Exposure
Li Xiang, Zheng Zhou Tobacco Research Institute of CNTC
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12:15-12:30
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Panel Discussion:
In Vitro
Dosimetry Determinations
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12:30-2:00
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Lunch - followed by Poster Viewing |
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Core Subject 4: Exposure Microenvironment/Physiology of Cells
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2:00-2:20
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Exposing What?: Overview of the Airway Tissue Exposure Site
Holger Behrsing, IIVS
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2:20-2:50
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In Vitro Toxicology of E-cigarettes and Other Tobacco Products
Irfan Rahman, University of Rochester
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2:50-3:05
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Panel Discussion: Exposure Microenvironment/Physiology of Cells |
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3:05-3:15
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Guidance for Breakout Groups:
- In Vitro Exposure Systems
- Dosimetry
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3:15-3:30
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Break |
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3:30-5:50
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Breakout Groups |
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5:30-6:30
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Poster Reception |
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6:30
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Dinner on your own
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April 6, 2016 - 8:30-3:15
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8:30-9:00
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Continental Breakfast
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9:00-9:20
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3D Lung Tissue Constructs, Lung- on- a-Chip and Response to Toxicants
Sonia Grego, RTI International
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9:20-9:40
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Quantitative High-Throughput Gene Expression Analysis Using a Modified
RASL-seq Platform Enables Treatment-Response Kinetic Analysis for Risk Assessment
Pei-Hsuan Chu, NIH/National Center for Advancing Translational Sciences
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9:40-10:00
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Predicting Exposure Response in the Airway: Integrating Cellular Signaling and Epigenetics Through the Epigenetic Seed and Soil Model of Interindividual Variability
Shaun McCullough, US EPA
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10:00-10:15
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Panel Discussion:
Promising Technologies
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10:15-10:30
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Break
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10:30-12:00
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Moderated Breakout Groups from Day2
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12:00-1:00
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Lunch
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1:00-2:00
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Breakout Group Discussions Wrap-up
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2:00-2:30
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Panel Discussion: Ways Forward in Normalizing Technology in a Regulatory Environment
Christopher Proctor, British American Tobacco
Neil Wilcox, FDA and Lorillard (retired)
Jack Fowle, EPA (retired)
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2:30-3:15
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Reports from Breakout Groups and Workshop Conclusion
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