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Dr. Randolph
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Dr. Randolph and our team of clinicians!
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Dr. Randolph's Pharmacy & Wellness Store
8am-6pm Mon-Fri
9am-2pm Saturday
Suite 100
1891 Beach Blvd., Jacksonville Bch, FL 32250
Pharmacy:
904-746-3046
Wellness Store:
904-249-4372
medshop@
cwrandolph.com
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Ageless & Wellness News
Volume 2, Number 20
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"When your body's overabundance of estrogen is neutralized with bioidentical progesterone, your breast cells are no longer exposed to high estrogen, and a causative factor for breast cancer is, for the most part, held in check
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-- C.W. Randolph, Jr. M.D.
This month we take a look at the role of estrogen dominance in breast cancer. Remember to "
Shop Now" at the
Wellness Store online
to help us support
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Dr. Randolph explains how we evaluate and treat hormone imbalance |
The Donna Foundation for Breast Cancer Awareness Month!
And continue the
conversation with us online!
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Estrogen Dominance and Breast Cancer
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Solid medical science and clinical studies have established that an underlying and untreated condition of "estrogen dominance" significantly increases your breast cancer risk: women who develop breast cancer have higher estrogen levels than women without breast cancer. Some studies have also shown that women who had been treated for breast cancer, and who continued to have high estrogen levels, had a return of the disease sooner than breast cancer survivors with lower estrogen levels.
The reason is that one of estrogen's functions in the body is to foster cell growth, or "cell proliferation." At a cellular level, unchecked cell growth can be a precursor for cancer.
Estrogen dominance can lead to cancer in one of two ways. The first has to do with the concentration of each of the three different forms of estrogen--estrone, estradiol, and estriol--circulating within the body. Estrone and estradiol both work within the body to increase expression of a gene (BCL-2) that causes cell division (development and growth), particularly in hormone-sensitive tissue such a breast or uterine lining. If unchecked, this cell proliferation can lead to cancer. In fact, nearly every risk factor for breast and uterine cancer can be either directly or indirectly linked to an increase in estrone, estradiol or their receptor activity. One such study in 2008 determined that high levels of estradiol were associated with significantly higher incidence of breast cancer recurrence.(1)
Note that Premarin, one of the most popular "synthetic" hormone replacement drugs, is composed of 49.3% estrone, almost
ten times the amount that occurs naturally in the body--is it any wonder that this drug was found to increase risk of invasive breast cancer in post-menopausal women by 41 percent?
The second factor influencing your cancer risk has to do with how your body metabolizes its estrogen. Estrogen can be "metabolized" (converted) down a "bad" pathway--one that is more cancer inducing--or a "good" pathway--one that is more cancer protective. The chemical name for the "bad" pathway is 16-hydroxyestrone. The "good" pathways are 2-hydroxyestereone and 2-hydroxyestradiol. Each woman's estrogen metabolism is different, so the balance between your "good" and "bad" pathways is unique.
The balance of anti-carcinogenic and pro-carcinogenic estrogen can be investigated with a urine test (trademarked Estronex).
Studies have demonstrated that post-menopausal women with more hydroxylation along the 2-pathways have a lower risk of breast cancer.(2) Some studies suggest that this is also the case for pre-menopausal women, but due to the varying levels of menstruating women's hormones, it is more challenging to conduct research. (Imagine trying to coordinate hundreds of volunteers to schedule blood draws on a certain representative day of their menstrual cycles!)
Our practice treats about 7,000 patients (of varying ages) each year with BHRT, and only a handful have developed breast cancer during more than two decades of prescribing bioidentical progesterone to balance the effects of estrogen dominance.
When your body's overabundance of estrogen is neutralized with bioidentical progesterone, your breast cells are no longer continuously exposed to high estrogen, and a causative factor for breast cancer is, for the most part, held in check.
(1) Cheryl L. Rock, Shirley W. Flatt, Gail A. Laughlin, et al., "Reproductive Steroid Hormones and Recurrence-Free Survival in Women with a History of Breast Cancer," Cancer Epidemiology Biomarkers and Prevention 17 (2008): 614-20.
(2) Roni T. Falk, Louise A. Brinton, Joanne F. Dorgan, et al., "Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: a nested case-control Study," Breast Cancer Research 15 (2013): online 2013 Apr 22.
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Breast Cancer Awareness Month
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THINK #PINK!
This October, we are proud
to participate in National
Breast Cancer Awareness
Month. Breast cancer is the
second most common kind
of cancer in women. About 1
in 8 women born today in
the United States will get
breast cancer at some point. Approximately
80% of women who develop breast cancer do
not have a family history of it. Talk to one of our clinicians at
your next visit about how you can protect your breast health.
We can help you find the best combination of bioidentical
hormone therapies and supplements for your individual
needs.
For more information:
National Breast Cancer Foundation, Inc.
BreastCancer.org
American Cancer Society
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Please let us know how we can help you on your path to optimal aging and wellness!
To Your Health,
Dr. Randolph
Ageless & Wellness Medical Center
1891 Beach Blvd., Suite 200
Jacksonville Beach, FL 32250
904.249.3743
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On ALL Supplements!
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EVERY Saturday
at Dr. Randolph's Pharmacy & Wellness Store
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Cannot be combined with any other sale/offer. Not available online. Only available at the Wellness Store in Jacksonville Beach, FL.
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